What condition can potentially lead to RV outflow obstruction and result in Eisenmenger’s syndrome?

Eisenmenger's syndrome is a complication that can arise from conditions that lead to significant left-to-right shunting of blood, which ultimately causes pulmonary hypertension. This situation occurs when there is a chronic increase in pressure within the pulmonary circulation, leading to right ventricular (RV) hypertrophy and potential outflow obstruction.

A large ventricular septal defect (VSD) allows blood to flow from the left ventricle to the right ventricle during systole, creating increased blood flow and pressure in the pulmonary circulation. Over time, this elevated pressure can cause changes in the pulmonary vasculature, leading to pulmonary artery hypertension. As this condition progresses, it can eventually reverse the shunt, causing blood to flow from right to left, which is characteristic of Eisenmenger's syndrome.

The potential for RV outflow obstruction arises from the right ventricle adapting to the increased workload, leading to hypertrophy and possibly to physical obstruction as the right ventricular outflow tract becomes narrowed due to muscular changes or due to elevated pressures in the pulmonary circuit.

Other conditions listed, such as mitral regurgitation, atrial septal defect, and coarctation of the aorta, may lead to various forms of heart failure or pulmonary issues