What is a common trigger for both Stevens-Johnson Syndrome and TEN?

Mycoplasma infection is recognized as a common trigger for both Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). These conditions, which are severe adverse reactions characterized by extensive skin and mucosal involvement, can be precipitated by infections, particularly those caused by the Mycoplasma genus, such as Mycoplasma pneumoniae. This organism is known to induce a hypersensitivity reaction that can lead to the immune-mediated damage of the skin, manifesting as SJS or TEN.

In contrast, while environmental allergens, bacterial infections, and contact dermatitis can trigger other types of allergic or hypersensitivity reactions, they are not specifically linked to the initiation of SJS or TEN. Mycoplasma infections have a well-documented association with these severe skin conditions, making it a key consideration in differential diagnosis and management of patients presenting with symptoms consistent with SJS or TEN.