What is the diagnosis for a patient exhibiting fever, widespread blisters, and erythematous/pruritic papules with involvement of mucous membranes and epidermal detachment?

The presentation of fever, widespread blisters, erythematous and pruritic papules, along with involvement of mucous membranes and epidermal detachment is characteristic of Stevens-Johnson syndrome (SJS). SJS is a severe, potentially life-threatening reaction, often triggered by medications or infections, that involves the skin and mucous membranes. The condition is marked by necrosis and detachment of the epidermis, usually affecting less than 10% of the body surface area, and can be accompanied by significant systemic symptoms, including fever and malaise.

In SJS, the combination of mucosal involvement and the types of skin lesions, such as blistering and extensive erythema, are crucial for diagnosis. The management of this condition typically involves immediate discontinuation of any offending agent, supportive care, and possibly hospitalization for severe cases.

The other options describe different conditions that do not match the full clinical picture as described. Toxic Epidermal Necrolysis (TEN) is a more severe form of drug reaction causing greater epidermal detachment (over 30% body surface area), while contact dermatitis usually presents as localized rash without systemic symptoms like fever. Viral exanthem refers to rashes associated with viral infections but typically does not