What is the most common drug class associated with Stevens-Johnson Syndrome?

Stevens-Johnson Syndrome (SJS) is a severe skin reaction often triggered by medication, and sulfa drugs are particularly notorious for this condition. Sulfonamides, which include certain antibiotics and diuretics, are known to induce hypersensitivity reactions that can lead to SJS. The mechanism behind this is thought to involve the formation of reactive metabolites that bind to proteins, leading to an immune-mediated response.

While other drug classes, such as NSAIDs and certain antidepressants, can also cause SJS, they are not the most commonly associated. Several studies have indicated that sulfa drugs account for a significant proportion of SJS cases, highlighting their role as a major culprit. This is especially notable in populations who might have a genetic predisposition to reactions against sulfonamides.

ACE inhibitors, generally used for hypertension and heart failure, are much less frequently reported in association with SJS, making them less relevant to this context. Understanding the drug classes associated with SJS can aid in proper patient management and prescribing practices, especially in individuals with known sensitivities.