Which medications are commonly associated with urticarial reactions?

Urticarial reactions, commonly known as hives, are often triggered by certain medications that provoke an allergic response or cross-reactivity in sensitive individuals. Antibiotics, particularly beta-lactams like penicillins, and non-steroidal anti-inflammatory drugs (NSAIDs) are well-established culprits in this context. Both classes of medications can evoke the immune system's response, leading to the development of urticaria.

Antibiotics frequently induce hypersensitivity reactions, and penicillins, in particular, are known for their potential to cause allergic reactions in a significant percentage of the population. NSAIDs may also lead to urticaria through direct pharmacological actions that can affect the skin as well as through immune-mediated mechanisms.

In contrast, topical corticosteroids are used to treat inflammatory skin conditions, including hives, rather than causing such reactions themselves. Antihistamines are typically employed to alleviate urticarial reactions rather than being a common cause of them. Thus, these medications are not significant contributors to urticaria. Therefore, the grouping of antibiotics and NSAIDs as commonly associated with urticarial reactions highlights the key role these medications play in such allergic responses.