Which of the following symptoms is associated with acute lymphoblastic leukemia (ALL)?

Bone pain is a common symptom associated with acute lymphoblastic leukemia (ALL). This type of leukemia originates in the bone marrow and can lead to the infiltration of leukemic cells within the bone marrow and surrounding tissues. As these abnormal cells proliferate, they can cause pressure on the bony structures, as well as disrupt normal hematopoiesis, leading to an increased incidence of bone pain as the disease progresses.

In children with ALL, bone pain can present as localized discomfort or general aches, and it is often more pronounced in areas such as the long bones. This symptom, combined with others like fatigue and easy bruising, often leads to further evaluation and diagnosis of the condition.

Other symptoms listed, such as abdominal pain, chest pain, and joint swelling, can occur in various other medical conditions but are less specific to ALL compared to bone pain. Abdominal pain may relate to organomegaly associated with leukemia or other gastrointestinal issues, chest pain might arise from different causes such as respiratory infections, and joint swelling may point to other inflammatory or infectious processes.