Which treatment is generally first-line for mild acne vulgaris?

Topical retinoids are considered the first-line treatment for mild acne vulgaris due to their efficacy in regulating skin cell turnover, reducing the formation of comedones (the precursors to acne lesions), and promoting the resolution of existing acne. They work by preventing the clogging of hair follicles, which is a primary contributing factor to acne development.

Additionally, topical retinoids help to alleviate inflammation associated with acne, making them a versatile choice for addressing both the causes and effects of the condition. They are typically well-tolerated and can be used in conjunction with other treatments as required, making them a foundational element in the management of mild acne.

Other treatments available for acne have their proper contexts and indications, but for mild cases, topical retinoids are most effective as an initial therapy. Isotretinoin, for example, is reserved for more severe or resistant acne cases due to its potency and potential side effects. Oral antibiotics target inflammation and bacteria but are better suited for moderate to severe acne. Spironolactone is typically used for hormonal acne, primarily in females, and is not a first-line therapy for general mild acne vulgaris.